Which district in Manila is described as the main commercial area with various shops and restaurants?

The main commercial area in Manila, known for its abundance of shops and restaurants, is the district of Ermita. This area has long been recognized for its vibrant nightlife and commerce, featuring a mix of traditional and modern establishments that cater to both locals and tourists. Ermita is historically significant as well, housing many cultural and historical landmarks, making it a bustling hub for shopping and dining.

While Sta. Cruz is an important neighborhood, it is more residential and does not have the same level of commercial activity as Ermita. San Miguel is primarily known for government institutions, including Malacañang Palace, and isn't typically associated with commercial establishments. Pandacan, on the other hand, is more industrial and residential and does not possess the commercial vibrancy seen in Ermita. Thus, Ermita stands out as the correct answer because of its recognized status as the main commercial destination in Manila.